Gut and Digestion Bundle

Enzyme Complex PRO

Recommended intake: Consume 1 capsule before main meals.

ProbioBalance IBS probiotics

Recommended daily intake: consume 1-2 capsules daily with a meal (preferably dinner).

Liver Regeneration Complex

Recommended daily intake: 1-2 capsules daily during a meal (preferably dinner).

Fish Omega 3 FORTE

Recommended daily intake: 1 capsule, twice a day. Best taken with meals (preferably breakfast and dinner).

Ingredients: Milk thistle seed extract (PhospoComplex®) (Silibin Fosfolipid Complex) standardized for silybin, L-ornithine-L-aspartate, milk thistle seed extract standardized for 80% silymarin and 30% silybin, Choline (VitaCholine®) artichoke standardized to 5% cynarin, barberry root extract (Berberis Aristata) standardized to 99% berberine sulfate, L-cysteine, N-acetyl-L-cysteine ​​(NAC), L-methionine, dandelion root extract, turmeric extract long (curcumin 3® (95% curcumin), reduced L-glutathione, black pepper extract (95% piperine), capsule shell (binding agent: hydroxypropyl methylcellulose).

Recommended daily dose: 1-2 capsules daily during a meal.

Ingredients: Digezyme® complex including: Alpha amylase (from Aspergillus oryzae), neutral protease (from Bacillus licheniformis), lactase (from Aspergillus oryzae), lipase (from Aspergillus oryzae), cellulase (from Trichoderma reesei), Fibregum ™ - Acacia fiber (prebiotic), LactoWise®: (Bacillus coagulans vieble spore MTCC 5856) (probiotic), Glactomannan (prebiotic)), capsule shell (hydroxypropyl methylcellulose).

Ingredients: Prebiotic - Fibregum ™ Bio LAW polysaccharide (aw <0.2%), Plantain - extract (Plantago Lanceolata), BIFIFOS W11 ™ Bifidobacterium longum W11 ™, Lactobacillus plantarum LP01, Bifidobacterium breve BR03, Lactobacillus LA02 glycerol fatty acid esters, capsule shell (hydroxypropyl methylcellulose).

Ingredients: anchovy FISH oil (50% EPA / 25% DHA); shell components: beef gelatin, glycerol (humectant), water.

References:

1. Digestive Enzyme Supplementation in Gastrointestinal Diseases

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini, and Giovanni Cammarota
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4923703/

2. Efficacy of digestive enzyme supplementation in functional dyspepsia: A monocentric, randomized, double-blind, placebo-controlled, clinical trial
Hammad Ullah, Alessandro Di Minno, Roberto Piccinocchi , Daniele Giuseppe Buccato , Lorenza Francesca De Lellis , Alessandra Baldi , Hesham R. El-Seedi , Shaden,A.M. Khalifa , Gaetano Piccinocchi , Xiang Xiao , Roberto Sacchi, Maria Daglia
https://www.sciencedirect.com/science/article/pii/S0753332223016566

3. The role of enzyme supplementation in digestive disorders
Mario Roxas
https://pubmed.ncbi.nlm.nih.gov/19152478/

4. Gut Health-Promoting Benefits of a Dietary Supplement of Vitamins with Inulin and Acacia Fibers in Rats
Malén Massot-Cladera, Ignasi Azagra-Boronat, Àngels Franch, Margarida Castell, Maria J. Rodríguez-Lagunas, and Francisco J. Pérez-Cano
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468733/

5. The effects of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults: A randomized, double-blind, placebo-controlled study
Muhammed Majeed, PhD, Kalyanam Nagabhushanam, PhD, Shaji Paulose, M Pharm, Sivakumar Arumugam, PhD, and Lakshmi Mundkur, PhD
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982755/

6. Bifidobacterium longum W11: Uniqueness and individual or combined clinical use in association with rifaximin
Francesco Di Pierro , Marco Pane
https://pubmed.ncbi.nlm.nih.gov/33745570/


7. Immunomodulatory Effects of Bifidobacterium longum W11 Produced Exopolysaccharide on Cytokine Production
Rosanna Inturri , Katia Mangano , Maria Santagati , Mariano Intrieri , Roberto Di Marco , Giovanna Blandino
https://pubmed.ncbi.nlm.nih.gov/29278212/

8. Lactobacillus plantarum LP01, Lactobacillus lactis subspecies cremoris LLC02, and Lactobacillus delbrueckii LDD01 in patients undergoing bowel preparation
Bonavina Luigi, Arini Andrea, Ficano Leonardo, Iannuzziello Donato, Pasquale Luigi, Emanuele Aragona Salvo, Drago Lorenzo, and Ciprandi Giorgio, Italian Study Group on digestive disorders
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776169/

9. Lactiplantibacillus plantarum Regulated Intestinal Microbial Community and Cytokines to Inhibit Salmonella typhimurium Infection
Rui-Han Liu An-Qi Sun , Ye Liao , Zheng-Xu Tang , Shi-Han Zhang , Xin Shan , Jing-Tao Hu
https://pubmed.ncbi.nlm.nih.gov/36074298/

10. Therapeutic Microbiology: The Role of Bifidobacterium breve as Food Supplement for the Prevention/Treatment of Paediatric Diseases
Nicole Bozzi Cionci, Loredana Baffoni, Francesca Gaggìa, and Diana Di Gioia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265827/

11. Supplementation with Bifidobacterium breve BR03 and B632 strains improved insulin sensitivity in children and adolescents with obesity in a cross-over, randomized double-blind placebo-controlled trial
Arianna Solito, Nicole Bozzi Cionci, Matteo Calgaro, Marina Caputo, Lucia Vannini, Iderina Hasballa, Francesca Archero, Enza Giglione, Roberta Ricotti, Gillian Elisabeth Walker, Antonella Petri, Emanuela Agosti, Giorgio Bellomo, Gianluca Aimaretti, Gianni Bona, Simonetta Bellone, Angela Amoruso, Marco Pane, Diana Di Gioia, Nicola Vitulo, Flavia Prodam
https://www.sciencedirect.com/science/article/pii/S0261561421002867

12. Recent Development of Probiotic Bifidobacteria for Treating Human Diseases
Jun Chen, Xinyi Chen, and Chun Loong Ho
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8727868/

13. Mechanisms and therapeutic effectiveness of lactobacilli
Alessandro Di Cerbo, Beniamino Palmieri, Maria Aponte, Julio Cesar Morales-Medina, and Tommaso Iannitti
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789713/

14. A review on the mechanisms of the effect of silymarin in milk thistle (Silybum marianum) on some laboratory animals
Roshanak Khazaei, Alireza Seidavi, and Mehrdad Bouyeh
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8788984/

15. L-Ornithine L-Aspartate (LOLA) as a Novel Approach for Therapy of Non-alcoholic Fatty Liver Disease
Ali Canbay & Jan-Peter Sowa
https://link.springer.com/article/10.1007/s40265-018-1020-5

16. Choline’s role in maintaining liver function: new evidence for epigenetic mechanisms
Mihai G. Mehedint and Steven H. Zeisel
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3729018/

17. Effects of Artichoke Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Mohammad Reza Amini, Fatemeh Sheikhhossein, Alireza Talebyan, Elham Bazshahi, Farhang Djafari, and Azita Hekmatdoost
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9348909/

18. Berberine in Non-Alcoholic Fatty Liver Disease—A Review
Anna Koperska, Agnieszka Wesołek, Małgorzata Moszak, and Monika Szulińska, Maciej Banach, Academic Editor and Amirhossein Sahebkar, Academic Editor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9459907/

19. Effects of Berberine on the Gastrointestinal Microbiota
Lichao Zhang, Xiaoying Wu, Ruibing Yang, Fang Chen, Yao Liao, Zifeng Zhu, Zhongdao Wu, Xi Sun, and Lifu Wang
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7933196/

20. N-Acetylcysteine Improves Liver Function in Patients with Non-Alcoholic Fatty Liver Disease, Manouchehr Khoshbaten, Akbar Aliasgarzadeh, Koorosh Masnadi, Mohammad K Tarzamani, Sara Farhang, Hosain Babaei, Javad Kiani, Maryam Zaare, and Farzad Najafipoor
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270338/

21. Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication

Zhanghao Li, Feixia Wang, Baoyu Liang, Ying Su, Sumin Sun, Siwei Xia, Jiangjuan Shao, Zili Zhang, Min Hong, Feng Zhang, and Shizhong Zheng
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7714782/

22. Protective Effects of Taraxacum officinale L. (Dandelion) Root Extract in Experimental Acute on Chronic Liver Failure
Iulia Olimpia Pfingstgraf, Marian Taulescu, Raluca Maria Pop, Remus Orăsan, Laurian Vlase, Ana Uifalean, Doina Todea, Teodora Alexescu, Corina Toma, and Alina Elena Pârvu
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8063808/

23. Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study.
Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh & Atsushi Nakajima
https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-017-0652-3

24. Effect of aqueous extract of black pepper and ajwa seed on liver enzymes in alloxan-induced diabetic Wister albino rats
Maliha Sarfraz, Tanweer Khaliq, Junaid Ali Khan, and Bilal Aslam
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5447421/

25. Impact of Omega-3 Fatty Acids on the Gut Microbiota
Lara Costantini, Romina Molinari, Barbara Farinon, and Nicolò Merendino
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751248/

26. Understanding the Impact of Omega-3 Rich Diet on the Gut Microbiota
Blanca S. Noriega, Marcos A. Sanchez-Gonzalez, Daria Salyakina, and Jonathan Coffman
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808672/

Liver Regeneration Complex

Milk thistle Contraindications

Milk thistle should not be used by pregnant or breastfeeding women.

People with a history of hormone-related cancers, including breast, uterine, and prostate cancer, should not take milk thistle.

DO NOT take milk thistle if you are allergic to ragweed, marigolds, chrysanthemums, chamomile, yarrow, or daisies.

Artichoke Contraindications
Artichoke is contraindicated in people with duct obstruction and should be used with extreme caution if the individual has gallstones (biliary lithiasis).

Barberry Contraindications
Use with caution in the presence of irregular heartbeat.

Dandelion Contraindications

In some people, dandelion might cause increased stomach acid and heartburn. It may also irritate the skin. People with kidney or gallbladder problems, or gallstones should consult their doctors before eating dandelion.

N-ACETYL CYSTEINE (NAC) Contraindications

NAC may strengthen the effects of some medications that suppress the immune system, such as azathioprine (Imuran), cyclophosphamide (Cytoxan), or prednisone (Deltasone). Do not take NAC with these medications without consultation with a doctor.

Turmeric Contraindications

People with bile duct problems, people taking anticoagulant or antidiabetic medications and people who had surgery within the past 2 weeks should avoid turmeric.

Enzyme Complex PRO

Contraindications
* Hypersensitivity to any ingredient
* Acute pancreatitis, acute exacerbation of chronic pancreatitis

ProbioBalance IBS probiotics & prebiotics

Probiotics are considered as safe for most people.

Probiotics are not recommended for use in a few serious medical conditions, which are listed below:

* For those who are severely immunosuppressed
* For those who have pancreatitis
* For those that have melaena (dark blood in their faeces)
* For those with a central venous catheter

Fish Omega 3 FORTE

Possible interactions include:

* Anticoagulant and antiplatelet drugs, herbs, and supplements.

These types of drugs, herbs, and supplements reduce blood clotting. Taking fish oil supplements with them might increase the risk of bleeding.

* Blood pressure drugs, herbs, and supplements.

Taking fish oil supplements can slightly lower blood pressure. Taking these supplements with blood pressure drugs might increase the effects on blood pressure.

* Orlistat, Xenical, Alli.
Taking fish oil with this weight-loss drug might decrease the absorption of fish oil. Consider taking the supplement and drug two hours apart.

* Contraceptive drugs. Some contraceptive drugs might interfere with the effect fish oil typically has on triglycerides. Consult your doctor.

* Vitamin E. Taking fish oil can decrease vitamin E levels.

Delivery is £3.99, Royal Mail Tracked 48 (2-3 busines days).

Next day delivery (Tracked 24) available.

Orders placed before 1pm on business days are dispatched on the same day.